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Fast Facts: CAR T-Cell Therapy
Chimeric antigen receptor (CAR) T cells are genetically engineered immune cells that can seek out and destroy cancer cells. The results from their use in cancer immunotherapy have been very promising, but treatment is often associated with frequent, serious short-term toxicities. 'Fast Facts: CAR-T Therapy' explains what CAR T cells are and how they were developed, discusses the results of clinical trials and the management of toxicities, and outlines future improvements and applications. It is ideal reading for any healthcare professional wanting to know more about this exciting therapeutic field. Table of Contents: ‧ CAR T cells ‧ Clinical application ‧ Practical aspects ‧ Future directions
- Cover
- Title Page
- Copyright
- Contents
- List of abbreviations
- Introduction
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CAR T cells
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The immune system
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Structure of CAR T cells
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Gene transfer
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The importance of co-stimulation
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Targets
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Clinical application
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Approved CAR T-cell products
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Problems delivering CAR T therapy
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Treatment outcomes: resistance and relapse
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Practical aspects
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The process
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CAR T-cell manufacturing failure
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Adverse events
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The logistics of CAR T therapy
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Future directions
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Improving efficacy
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Positioning of CAR T therapy
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Decreasing toxicity
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Improving gene transfer
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Dual targeting
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Allogeneic CAR T cells
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Alternative host cells
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New targets and cancer types
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Other strategies
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- Useful resources
- Index
- 出版地 ： 德國
- 語言 ： 德文
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