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Clinical Recovery from CNS Damage

出版社
出版日期
2013/07/08
閱讀格式
EPUB
書籍分類
學科分類
ISBN
9783318023091

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After decades of focusing on how to alleviate and prevent recurrence of acute CNS injuries, the emphasis has finally shifted towards repairing such devastating events and rehabilitation. This development has been made possible by substantial progress in understanding the scientific underpinnings of recovery as well as by novel diagnostic tools, and most importantly, by emerging therapies awaiting clinical trials. In this publication, several international experts introduce novel areas of neurological reorganization and repair following CNS damage. Principles and methods to monitor and augment neuroplasticity are explored in depth and supplemented by a critical appraisal of neurological repair mechanisms and possibilities to curtail disability using computer or robotic interfaces. Rather than providing a textbook approach of CNS restoration, the editors selected topics where progress is most imminent in this labyrinthine domain of medicine. Moreover, the varied background and origins of the contributors lend this book a truly global perspective on the current state of affairs in neurological recovery.
  • Cover Page
  • Front Matter
    • Frontiers of Neurology and Neuroscience
    • Title Page
    • Copyright
    • Contents
    • Preface
  • Mechanisms of Functional Recovery after Stroke
    • Abstract
    • The Impact of Stroke
    • Structural Bases of Functional Recovery
      • Neuroblast Migration
      • Angiogenesis
      • Axonal Sprouting and Regeneration
      • Specific Issues in Intracerebral Hemorrhage
    • Functional Cortical Reorganization
      • Diaschisis
      • Cortical Reorganization
      • Uncrossed Fibers from the Contralesional Hemisphere.
      • Recovery from Miscellaneous Stroke
    • Pharmacologic Options Targeting Functional Improvement
      • Central Noradrenergic Stimulation
      • Serotoninergics
      • Dopaminergics
    • Nonpharmacologic Therapeutic Options
      • Noninvasive Cortical Stimulation
      • Constraint-Induced Movement Therapy
    • Acknowledgements
    • References
  • Diagnostic Approach to Functional Recovery: Functional Magnetic Resonance Imaging after Stroke
    • Abstract
    • Background
    • What Is Functional Magnetic Resonance Imaging?
    • How Can Functional Magnetic Resonance Imaging Be Used to Assess Brain Function after Stroke?
    • Feasibility of Functional Magnetic Resonance Imaging in a Clinical Post-Stroke Setting
    • Network Reorganization after Stroke
    • Assessment of Brain Reorganization after Stroke
      • Cross-Sectional Functional Magnetic Resonance Imaging Studies in Motor Stroke
      • Longitudinal Functional Magnetic Resonance Imaging Studies in Motor Stroke
    • Predicting Recovery Based on Early Functional Magnetic Resonance Imaging
    • Mapping Treatment-Induced Functional Reorganization
    • Methodological Considerations
    • Summary and Outlook
    • Acknowledgement
    • References
  • Diagnostic Approach to Functional Recovery: Diffusion-Weighted Imaging and Tractography
    • Abstract
    • Imaging White Matter Damages
      • Clinical Relevance of Studying White Matter
      • Characterizing White Matter Damages
    • Current Clinical Applications
      • Diagnosis and Functional Prognosis of Brain Injuries
      • Probing Compensatory/Adaptive Mechanisms after Brain Injuries
    • Future Methodological Challenges and Clinical Applications
    • Conclusion
    • References
  • Compensatory Contribution of the Contralateral Pyramidal Tract after Experimental Cerebral Ischemia
    • Abstract
    • Contribution of the Area Contralateral to the Stroke Lesion: A Human Case and Animal Models
    • Acute Phase Remodeling Achieves Compensation: The Case of the Area Contralateral to the Lesion
    • Correlation of Rehabilitation: Acute Is Best?
    • References
  • Compensatory Contribution of the Contralateral Pyramidal Tract after Stroke
    • Abstract
    • Role and Plasticity of the Pyramidal Tract
    • Preserved Ipsilateral Corticospinal Tract Function Is a Plausible Mechanism of Motor Recovery after Stroke
    • Role of the Ipsilateral Corticospinal Tract in Patients with Motor Recovery after Stroke
    • Conclusion
    • References
  • Regeneration of Neuronal Cells following Cerebral Injury
    • Abstract
    • Hematopoietic Stem Cells
    • Mesenchymal Stem Cells
    • Endothelial Progenitor Cells
    • Very Small Embryonic-Like Stem Cells
    • Conclusion
    • Acknowledgement
    • References
  • Translational Challenge for Bone Marrow Stroma Cell Therapy after Stroke
    • Abstract
    • Basic Aspects of Bone Marrow Stromal Cell Transplantation
    • Translational Aspects of Bone Marrow Stromal Cell Transplantation
    • Conclusion
    • Acknowledgements
    • References
  • Experimental Evidence and Early Translational Steps Using Bone Marrow Derived Stem Cells after Human Stroke
    • Abstract
    • Neuronal Regeneration Is Activated after Cerebral Ischemia
    • Angiogenesis Is Essential for the Survival of Injury-Induced Neuronal Stem Cells
    • Cell-Based Therapy to Enhance Neurogenesis in Ischemic Brain
    • Clinical Trials to Enhance Neurogenesis in Patients after Stroke
    • Future Cell-Based Therapy for Prevention of Cerebrovascular Diseases
    • Conclusion
    • References
  • Therapeutic Drug Approach to Stimulate Clinical Recovery after Brain Injury
    • Abstract
    • Mechanisms Underlying Clinical Recovery
    • Genetic Variability
    • Plasticity
    • Regeneration
    • Stimulating Plasticity by Neuropharmaceuticals
      • Amantadine
      • Catecholaminergics
      • Cholinergics
      • Serotoninergics
    • Signaling Molecules
      • Erythropoietin
      • Granulocyte Colony-Stimulating Factor
    • Stimulating Regeneration by Neuropharmaceuticals
    • Neutralizing Axonal Growth Inhibitors
    • References
  • Rehabilitation and Plasticity
    • Abstract
    • Mechanisms of Training
      • Animal Models
      • Studies in Humans
    • Therapeutic Principles
      • Timing
      • Intensity
      • Motivation
      • Elements of Effective Training
      • Therapy Using Robots
      • Supportive Therapies
    • Evidence in Neurorehabilitation
    • References
  • A Brain-Computer Interface to Support Functional Recovery
    • Abstract
    • Running a Brain-Computer Interface
    • Use for Disabled People
    • Our Brain-Computer Interface Efforts
    • References
  • Novel Methods to Study Aphasia Recovery after Stroke
    • Abstract
    • Shaping Language-Related Neural Processing with Transcranial Magnetic Stimulation
    • Shaping Language-Related Neural Processing with Transcranial Direct Current Stimulation
    • Right-Hemisphere Contributions to Language Processing in the Healthy Brain
    • Reorganization of Language Networks after Stroke - Evidence from Repetitive Transcranial Magnetic Stimulation Studies
    • Reorganization of Language Networks after Stroke - Evidence from Transcranial Direct Current Stimulation Studies
    • A Hierarchical Model of Aphasia Recovery after Stroke
    • Conclusions and Future Directions
    • References
  • Role of Repetitive Transcranial Magnetic Stimulation in Stroke Rehabilitation
    • Abstract
    • Principles of Repetitive Transcranial Magnetic Stimulation and Biological Aspects
    • Repetitive Transcranial Magnetic Stimulation Modifies Sensorimotor and Cognitive Recovery
    • Conclusion
    • References
  • Influence of Therapeutic Hypothermia on Regeneration after Cerebral Ischemia
    • Abstract
    • Hypothermia and Regeneration in Experimental Models
      • Neurogenesis
      • Neuronal Connectivity
      • Angiogenesis
      • Gliogenesis
    • Conclusion and Future Perspectives
    • References
  • High Voltage Electric Potentials to Enhance Brain-Derived Neurotrophic Factor Levels in the Brain
    • Abstract
    • Specific Types of Electric Stimulation
    • The High-Voltage Electric Field Therapy
    • Experimental Procedure and Treatment Protocol
      • Experiment 1 (Experimental Procedure in Mice)
      • Experiment 2 (Treatment Protocol in Humans)
      • Statistical Analysis
    • Results
      • Alterations in Brain-Derived Neurotrophic Factor Levels in the Mouse Brain (Experiment 1)
      • Alterations in Learning and Memory in Mice (Experiment 1)
      • Alterations in the Mouse Body Weight (Experiment 1)
      • Alterations in Body Weight in Humans (Experiment 2)
    • Discussion
    • Acknowledgements
    • References
  • Prevention of Post-Stroke Disuse Muscle Atrophy with a Free Radical Scavenger
    • Abstract
    • Muscle Changes with Ageing
    • Immobilization and Disuse Muscle Atrophy
    • Mechanisms of Disuse Atrophy
    • Long-Term Free Radical Scavenger Improves Functional Outcome of Stroke
    • Prevention of Muscle Atrophy with a Free Radical Scavenger
    • Conclusions
    • References
  • Author Index
  • Subject Index
  • 出版地 德國
  • 語言 德文

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