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Fast Facts: Bladder Cancer

出版社
出版日期
2018/02/05
閱讀格式
EPUB
書籍分類
學科分類
ISBN
9781910797655

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Our understanding of the biology of bladder cancer has advanced remarkably since the second edition of 'Fast Facts: Bladder Cancer' was published in 2006. Five new immunotherapies targeting the PD-1 axis were approved in 2016 and 2017 for the treatment of advanced bladder cancer, reflecting this transformative explosion in knowledge about the biology of the disease. This new era of targeted treatment offers hope to patients, particularly those with advanced disease. However, for clinicians it means a lot to understand in terms of how these immunotherapies are integrated into the treatment paradigm. Who they are suitable for? When are they best used? What is the optimal sequence of treatments for individual patients? This third edition of 'Fast Facts: Bladder Cancer' has been updated extensively throughout by two new authors, bringing a fresh perspective. Key updates include: ‧ the latest understanding of pathology and biology ‧ current standards for investigation, imaging and diagnosis ‧ the critical role that awareness of the significance of hematuria among patients and primary care health professionals can make to earlier detection at curable stages of the disease ‧ the roles of drugs, surgery and radiation therapy in treatment at different stages of bladder cancer, and when and how best to intervene, aided by understanding of the risk factors for disease relapse and progression ‧ a new chapter about immunotherapy for bladder cancer ‧ future trends in a rapidly evolving field. 'Fast Facts: Bladder Cancer' is a concise guide that will be of value to clinicians and health professionals involved in the detection and treatment of bladder cancer. This highly readable resource provides a comprehensive and current view of this complex disease, enabling informed discussions with patients. Contents: ‧ Epidemiology and etiology ‧ Pathology and biology ‧ Clinical presentation ‧ Investigations ‧ Management of non-muscle-invasive disease ‧ Management of muscle-invasive disease ‧ Management of advanced and metastatic disease ‧ Immunotherapy ‧ Future trends ‧ Useful resources
  • Cover
  • Title
  • Copyright
  • Contents
  • Glossary
  • Introduction
  • Epidemiology and etiology
    • Epidemiology
    • Etiology
  • Pathology and biology
    • Histology
    • Staging and grading
    • Molecular phenotype
    • Patterns of recurrence and spread
    • Mortality
  • Clinical presentation
    • Painless hematuria
    • Asymptomatic microscopic hematuria
    • Irritative symptoms
    • Recurrent urinary tract infections
    • Symptoms of local or distant spread
    • Delay in diagnosis
  • Investigations
    • History
    • Examination
    • Detailed investigation
  • Management of non-muscle-invasive disease
    • Basic principles
    • Initial surgical management
    • Prognostic factors
    • Prognostic groups
    • Intravesical therapy
    • Surveillance following initial diagnosis and treatment
  • Management of muscle-invasive disease
    • Radical cystectomy and pelvic lymphadenectomy
    • Peri-operative treatment for intermediate- or high-risk bladder cancer
    • Multimodality and bladder-preserving therapy
  • Management of advanced and metastatic disease
    • Systemic therapy for metastatic bladder cancer
    • Second and subsequent lines of chemotherapy
    • General principles of treatment
    • Palliation and best supportive care
  • Immunotherapy
    • Principles of immunotherapy
    • PD-1 axis
    • PD-1-targeted immunotherapies
    • Prediction of response
    • First-line studies
    • Adverse effects of immunotherapy
  • Future trends
    • Improving prevention
    • Earlier diagnosis
    • Better treatment of high-risk non-muscle-invasive disease
    • Improved use of existing therapies
    • Identification of biomarkers that allow better risk stratification and treatment selection
    • Development of new therapies and rational combinations
    • Better involvement of palliative and supportive care
  • Useful resources
  • Index
  • 出版地 德國
  • 語言 德文

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