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Fast Facts: Prostate Cancer
This is the tenth edition of this Fast Facts handbook since the first was published in 1996 – the many iterations are testament to the rapid changes in the field and steadily improving outlook for patients. This new edition introduces the Gleason grade grouping (Chapter 1), which has important prognostic value, and nomograms that are used to evaluate risk (Chapter 3). Our understanding of the genetics and underlying pathogenesis of prostate cancer is growing apace, leading to the identification of germline mutations and the development of genomic tests to help identify and direct therapy for those at greatest risk of developing clinically significant disease. They also provide reassurance for those patients who have opted for active surveillance (Chapters 3 and 5). Imaging techniques are also improving rapidly, particularly multiparametric MRI (Chapter 4). As this book is concise, fully up to date and evidence based, we believe it is an ideal resource for those general urologists, primary care providers, specialist nurses, trainees and allied healthcare professionals who want to get quickly up to speed in this fast-moving and ever-expanding field. Contents: ‧ Epidemiology and pathophysiology ‧ Diet, lifestyle and chemoprevention ‧ Screening and early detection ‧ Diagnosis, staging and prognostic indicators ‧ Management of clinically localized disease ‧ Managing recurrence after initial therapy ‧ Managing metastatic hormone-sensitive prostate cancer ‧ Management of castrate-resistant prostate cancer ‧ Survivorship and management of treatment-related side effects and complications
- Cover
- Title Page
- Copyright
- Contents
- List of abbreviations
- Introduction
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Epidemiology and pathophysiology
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Global patterns
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Risk factors
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Histological features
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Patterns of disease spread
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Diet, lifestyle and chemoprevention
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Effect on development
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Effect on progression
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Screening and early detection
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Early detection
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Screening
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Clinical symptoms
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Diagnosis, staging and prognostic indicators
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Diagnosis
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Staging
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Prognostic indicators
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Summary of diagnostic and staging options
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Management of clinically localized disease
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Active surveillance
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Radical prostatectomy
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Radiotherapy
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Watchful waiting
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Experimental techniques
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Antiandrogen monotherapy
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Management of local complications
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Managing recurrence after initial therapy
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Recurrence after prostatectomy
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Recurrence following radiation therapy
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Managing metastatic hormone-sensitive prostate cancer
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Oligometastatic cancer and widespread metastases
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Orchiectomy
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LHRH analogs
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LHRH antagonists
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Antiandrogens
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Maximal androgen blockade
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The timing of hormonal therapy
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Intermittent hormonal therapy
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ADT in combination therapy
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Local treatment of the primary tumor
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Treatment of oligometastatic disease
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Management of castrate-resistant prostate cancer
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Further hormonal manipulation
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Non-metastatic castrate-resistant prostate cancer
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Metastatic castrate-resistant prostate cancer
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Immunotherapy
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PARP inhibitors
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PSMA radioligand therapy
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Management of bone metastases
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Palliative care
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Treatment algorithm
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Survivorship and management of treatment-related side effects and complications
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Survivorship
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Sexual function
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Urinary and bowel symptoms
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Other side effects
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- Useful resources
- Index
- 出版地 : 德國
- 語言 : 德文
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